Protein Structure Fingerprint

Reveal Multiple Conformations for Protein Strucrure

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* Conversion
Covert protein 3D structure into digital description (PFSC)

* Folds
Convert protein sequence into folding variation matrix (PFVM)

* Alignment
Protein conformation alignment (PFSC alignment)

* Search
Search protein homologous conformations

* Targets
Find out multiple protein targets for small molecule

* PPI
Protein-protein interaction

* Mutations
Mutations cause folding difference

Reference:

Yang J. Comprehensive description of protein structures using protein folding shape code. Proteins 2008;71.3:1497-1518
Yang J. Protein Structure Fingerprint Technology. J Bioinform, Genomics, Proteomics 2018: 3(2): 1036
Yang J., etc. Comprehensive folding variations for protein folding. Proteins. 2022, 90(11), 1851-1872.

MISSION

Provide a solution for protein folding problem

Complete description for digitalized protein folding conformation

Protein structure prediction with conformational ensembles

Support drug discovery

KEY TECHNOLOGIES

Protein Structure Fingerprint technology:

PFSC: Protein Folding Shape Code
PFVM: Protein Folding Variation Matrix
FiveFold: Five amino acids as a folding element for protein structure prediction
PBSDD: Probe Binding Site for Drug Discovery

APPLICATIONS

Conformation alignment for protein comparison

High throughput screening protein homologous conformations from PDB

Comprehensive folding variations for any protein sequence from UniProt

Multiple conformations for intrinsically disordered protein (IDP)

Protein structure for mutation protein

Drug Discovery
Protein and peptide design
Antibody optimization
Multiple protein targets for small molecule drugs
Discover new targets for existing drugs

FEATURES

Provide complete folding description for protein for given 3D structure

Provide complete folding variations for any protein according sequence

Provide lead information of protein for drug discovery