- Conformation Analysis
- Protein Structure Alignment
- Protein Misfolding vs. Alzheimer Disease
- Fragment Search
- Evaluate Structural Similarity for Proteins with Diverse Degrees in Homology
- Mutation Analysis
- Analysis of CDR Loops in Antibody
- Comparison of Insulin Receptor vs. IGF-1 Receptor
- Drug Binding Site
- Predicting Off Target Hits in Drug Discovery
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Analysis of CDR Loops in Antibody
Structure Comparison of Monoclonal Antibody (Rituximab) against CD20
- The general structure of all antibodies is very similar
- It is composed of one constant and one variable domain from each heavy and light chain of the antibody
- The loops at the tip are referred to as the complementarily determining regions (CDRs)
- The CDR loops are extremely variable, allowing millions of antibodies with slightly different tip structures, as antigen binding sites
- Rituximab is a widely used monoclonal antibody drug for treating certain lymphomasand autoimmune diseases. It is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells.
- There are two protein structure data (3BKY and 2OSL) available in PDB
- Fingerprint comparison for CDR loops of monoclonal antibody (Rituximab) is show below table.
Antigen-Antibody Recognition & Binding: Rituximab Fab fragment in complex with an epitope peptide of the large extra-cellular loop (residues 163–187) of CD20.
