- Conformation Analysis
- Protein Structure Alignment
- Protein Misfolding vs. Alzheimer Disease
- Fragment Search
- Evaluate Structural Similarity for Proteins with Diverse Degrees in Homology
- Mutation Analysis
- Analysis of CDR Loops in Antibody
- Comparison of Insulin Receptor vs. IGF-1 Receptor
- Drug Binding Site
- Predicting Off Target Hits in Drug Discovery
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Comparison of Insulin Receptor vs. IGF-1 Receptor
Three Domain Structure Alignment
- Rich structural data of insulin-like growth factor 1 rece ptor (IGF1R) and insulin receptor (INSR)has been accumulated, and the sequence alignment was applied in comparison.
- In this study, instead, the folding conformations of IGF1R and INSR are directly aligned for structural comparison. The crystal st ructures of first three domains of L1-CR-L2 structures of IGF1R (PDB ID: 1IGR) (Hubbard, 1997) and INSR (PDB ID: 2HR7) (Murzin, 1995) are available in PDB.
- The images of first three domains for IGF1R (1IGR) and INSR (chain A of 2HR7) are displayed in Fig.3.
- With PFSA approach, the folding structure alignment between IGF1R and INSR agrees with equence alignment.
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Reference:
- Yang J & Lee WH, Protein Structure Alphabetic Alignment, Protein Structure, Edited by Eshel Faraggi, InTech Publishers, (ISBN 978-953-51-0555-8), 2012, 133-156