- Conformation Analysis
- Protein Structure Alignment
- Protein Misfolding vs. Alzheimer Disease
- Fragment Search
- Evaluate Structural Similarity for Proteins with Diverse Degrees in Homology
- Mutation Analysis
- Analysis of CDR Loops in Antibody
- Comparison of Insulin Receptor vs. IGF-1 Receptor
- Drug Binding Site
- Predicting Off Target Hits in Drug Discovery
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Mutation Analysis
Analysis of Mutation in Type II Diabetes and Obesity
Mutation from Alanine (54) to Threonine (54) has been associated with insulin resistance. The PFSA reveals the difference on binding site.
•Solution Structure of Human Intestinal Fatty Acid Binding Protein with a Naturally-Occurring Single Amino Acid Substitution (A54T) that Is Associated with Altered Lipid Metabolism.
Reference:
Zhang, F., Luecke, C., Baier, L.J., Sacchettini, J.C., Hamilton, J.A. Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid meta, Biochemistry, 2003;42 (24), 7339 -7347.